beta-sitosterol: esterification by intestinal acylcoenzyme A: cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification
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منابع مشابه
Regulation of plasma cholesterol esterification by sphingomyelin: effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity.
Although sphingomyelin (SM) is the most abundant phospholipid in the plasma, next to phosphatidylcholine (PC), its physiological function in plasma is unclear. Here we employed plasma from various genetic models of mice which naturally differ in their plasma SM/PC ratios, to study the role of SM as a modulator of LCAT, the enzyme responsible for HDL maturation and the synthesis of cholesteryl e...
متن کاملSerum cholesterol esterification in liver disease. Combined determinations of lecithin: cholesterol acyltransferase and lipoprotein-X.
Indireet evidence suggests that lecithin: choles· terol acyltransferase (LCAT) is synthesized in the liver. There are, however, controversial reports in the literature correlating LCAT activity with various forms of liver disease. The purpose of this study was to determine LCAT activity in icteric pa· tients. These were classified not only by the conventional methods, but also with respect to t...
متن کاملCholesterol oxides inhibit cholesterol esterification by lecithin:cholesterol acyl transferase
Cholesterol oxides are atherogenic and can affect the activity of diverse important enzymes for the lipidic metabolism. The effect of 7b-hydroxycholesterol, 7-ketocholesterol, 25-hydroxycholesterol, cholestan-3b,5a,6b-triol,5,6b-epoxycholesterol, 5,6a-epoxycholesterol and 7a-hydroxycholesterol on esterification of cholesterol by lecithin:cholesterol acyl transferase (LCAT, EC 2.3.1.43) and the ...
متن کاملCholesterol esterification in rabbit plasma.
1. When [4-(14)C]cholesterol, attached to beta-globulin or dispersed with Tween 20, was incubated with fresh rabbit (New Zealand albino females) plasma, 30-47% esterification was observed. The optimum pH was 6.8. This esterification was accomplished by the transfer of fatty acids from the C-2 position of lecithin (phosphatidylcholine) to cholesterol. 2. There was no evidence that triglycerides ...
متن کاملLecithin:cholesterol acyltransferase (LCAT) mass; its relationship to LCAT activity and cholesterol esterification rate.
The relationship between plasma lecithin:cholesterol acyltransferase mass and enzyme activity and between mass and plasma cholesterol esterification rate was determined in 25 adult volunteers without overt disease (14 normolipidemic and 11 hyperlipidemic). Furthermore, the relationship of lecithin:cholesterol acyltransferase mass and cholesterol esterification rate to lipids, apoproteins, age, ...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1983
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)37981-5